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Kaposi's sarcoma-associated herpesvirus (KSHV) contains several open reading frames (ORFs) encoding

proteins capable of initiating signal transduction pathways. Among them is the K15 ORF, which consists of

eight exons encoding a protein with 12 predicted transmembrane domains and a cytoplasmic C terminus. When

transiently expressed, the 8-exon K15 transcript gives rise to a protein with an apparent molecular mass of 45

kDa. K15 interacts with cellular proteins, TRAF (tumor necrosis factor receptor-associated factor) and Src

kinases, and activates AP-1, NF-...